The Diagnosis and Treatment of Cancer Cachexia

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  • Takayama Koichi
    Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
  • Tanaka Satomi
    Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine

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  • がん悪液質の診断と治療

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Abstract

<p>Cancer cachexia is associated with weight loss, anorexia, and fatigue, and a deteriorated life prognosis and quality of life among cancer patients. The onset of cachexia involves various factors, including inflammatory cytokines and tumor products, leading to abnormalities in energy metabolism and degradation of the skeletal muscles. Fearon et al. proposed simple diagnostic criteria based on the degree of weight loss and promoted intervention at an early stage. However, the recognition of cancer cachexia is still low, so education on the state will be necessary in the future. In 2021, anamorelin, a ghrelin agonist, was approved as a therapeutic drug in Japan for the first time globally and is currently being used in clinical practice. However, drug therapy alone is not sufficient, and comprehensive treatment combined with nutritional therapy and exercise therapy is considered necessary for proper resolution. The development of new drugs, such as GDF-15 antibody, is also progressing, with further advances in cancer cachexia treatment expected in the future.</p>

Journal

  • Haigan

    Haigan 62 (3), 180-187, 2022-06-20

    The Japan Lung Cancer Society

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