Functional interaction between the intestinal microbiota and enteroendocrine cells

DOI
  • Tsuboi Takashi
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
  • Harada Kazuki
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
  • Nakamura Takumi
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
  • Osuga Yuri
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo

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  • 腸内細菌叢と消化管内分泌細胞との機能連関

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Abstract

<p>Glucagon-like peptide-1 (GLP-1) is secreted by enteroendocrine L cells and promotes insulin secretion and suppresses appetite. GLP-1 secretion is regulated by various substances in the lumen of the gastrointestinal tract, neurotransmitters and hormones in the blood, and various metabolites produced by the intestinal microflora, but the detailed regulation mechanism is unknown. In the present review, we will introduce the effects of amino acids and intestinal bacterial metabolites on GLP-1 secretion.</p>

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