Preliminary Study of Expression of γ-H2AX and 53BP1 in Medical Radiation Workers

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  • Basri Iin Kurnia Hasan
    Center for Technology of Radiation Safety and Metrology National Nuclear Energy Agency Jl.
  • Lusiyanti Yanti
    Center for Technology of Radiation Safety and Metrology National Nuclear Energy Agency Jl.
  • Rahajeng Nastiti
    Center for Technology of Radiation Safety and Metrology National Nuclear Energy Agency Jl.
  • Rahardjo Tur
    Center for Technology of Radiation Safety and Metrology National Nuclear Energy Agency Jl.
  • Yusuf Darlina
    Center for Technology of Radiation Safety and Metrology National Nuclear Energy Agency Jl.
  • Soetopo Setiawan
    Hasan Sadikin Hospital, Jl. Pasteur No.38 Bandung, 40161 INDONESIA

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<p>Currently a huge number of professional and technical personnel in medicine, dentistry, and veterinary medicine are exposed to radiation while administering various radiologic procedures such as diagnostic, therapeutic, interventional, and nuclear medicine. The radiation workers in medical area have risks to be exposed to ionizing radiation that also potentially cause DNA damage. In this study, 43 blood samples were taken from medical radiation workers in three hospitals (Hasan Sadikin, Medistra, and Betsaida Hospitals) and administrative staff served as control. They were grouped according to gender (man and woman) and duration of working time (0 - 20 and > 20 years). The expression of γ-H2AX and 53BPI foci was detected by using antibody of γ-H2AX Ser-139 and 53BPI under fluorescence microscope observation. The mean γ-H2AX and 53BPI foci in medical radiation worker and control were 0.22 and 0.12 and 0.38 and 0.17 respectively (P > 0.05). There was correlation between γ-H2AX foci and 53BP1 (P < 0.0001) and no statistically significant of -H2AX and 53BP1 foci in behalf on gender and duration of working time of radiation workers (P > 0.05). It can be concluded that potency of DNA damaged that detected by γ-H2AX and 53BP1 foci between medical radiation worker and administrative staff and their duration of working time was not different.</p>

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