Non-High-Density Lipoprotein Cholesterol and Risk of Cardiovascular Disease: The Japan Epidemiology Collaboration on Occupational Health Study
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- Hu Huan
- Department of Public Health, Tokushima University Graduate School of Biomedical Sciences Department of Epidemiology and Prevention, National Center for Global Health and Medicine
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- Fukunaga Ami
- Department of Epidemiology and Prevention, National Center for Global Health and Medicine
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- Yokoya Toshitaka
- Mitsubishi Heavy Industries, Ltd
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- Nakagawa Tohru
- Hitachi Health Care Center, Hitachi, Ltd
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- Honda Toru
- Hitachi Health Care Center, Hitachi, Ltd
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- Yamamoto Shuichiro
- Hitachi Health Care Center, Hitachi, Ltd
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- Okazaki Hiroko
- Mitsui Chemicals, Inc
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- Miyamoto Toshiaki
- NIPPON STEEL CORPORATION, EAST NIPPON WORKS Kimitsu Area
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- Sasaki Naoko
- Mitsubishi Fuso Truck and Bus Corporation
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- Ogasawara Takayuki
- Mitsubishi Fuso Truck and Bus Corporation
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- Gonmori Naoki
- East Japan Works (Keihin), JFE Steel Corporation
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- Yamamoto Kenya
- Division of Chemical Information, National Institute of Occupational Safety and Health
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- Hori Ai
- Department of Global Public Health, Faculty of Medicine, University of Tsukuba
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- Tomita Kentaro
- Healthplant Co., Ltd
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- Nagahama Satsue
- All Japan Labour Welfare Foundation
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- Konishi Maki
- Department of Epidemiology and Prevention, National Center for Global Health and Medicine
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- Katayama Nobumi
- Department of Epidemiology and Prevention, National Center for Global Health and Medicine
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- Morioka Hisayoshi
- Department of Public Health, Tokushima University Graduate School of Biomedical Sciences
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- Kabe Isamu
- KUBOTA Corporation
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- Mizoue Tetsuya
- Department of Epidemiology and Prevention, National Center for Global Health and Medicine
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- Dohi Seitaro
- Mitsui Chemicals, Inc
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<p> Aims: We aimed to investigate the association between non-high-density lipoprotein cholesterol (non-HDL-C) levels and the risk of cardiovascular disease (CVD) and its subtypes.</p><p>Methods: In this contemporary cohort study, we analyzed the data of 63,814 Japanese employees aged ≥ 30 years, without known CVD in 2012 and who were followed up for up to 8 years. The non-HDL-C level was divided into 5 groups: ＜110, 110-129, 130-149, 150-169, and ≥ 170 mg/dL. The Cox proportional hazards model was used to calculate the hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) for CVD and its subtypes associated with each non-HDL-C group, considering 130-149 mg/dL as the reference group.</p><p>Results: During the study period, 271 participants developed CVD, including 78 myocardial infarctions and 193 strokes (102 ischemic strokes, 89 hemorrhagic strokes, and 2 unknowns). A U-shaped association between non-HDL-C and stroke was observed. In the analysis of stroke subtypes, the multivariable-adjusted HR (95% CI) for hemorrhagic stroke was 2.61 (1.19–5.72), 2.02 (0.95–4.29), 2.10 (1.01–4.36), and 1.98 (0.96-4.08), while that for ischemic stroke was 1.54 (0.77-3.07), 0.91 (0.46-1.80), 0.73 (0.38-1.41), and 1.50 (0.87-2.56) in the ＜110, 110-129, 150-169, and ≥ 170 mg/dL groups, respectively. Individuals with elevated non-HDL-C levels had a higher risk of myocardial infarction.</p><p>Conclusions: High non-HDL-C levels were associated with an increased risk of myocardial infarction. Moreover, high and low non-HDL-C levels were associated with a high risk of stroke and its subtypes among Japanese workers.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ
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Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ 29 (9), 1295-1306, 2022-09-01
一般社団法人 日本動脈硬化学会