Effects of pulsed magnetic stimulation on slow to fast twitch muscle fiber transformation and mitochondrial dysfunction in skeletal muscle with heart failure

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  • Hirabayashi Takumi
    Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences Department of Rehabilitation, Nose Hospital
  • Nakanishi Ryosuke
    Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences Faculty of Rehabilitation, Kobe International University
  • Maeshige Noriaki
    Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences
  • Fujino Hidemi
    Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences

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Other Title
  • 心不全に伴う骨格筋の速筋化とミトコンドリア機能障害に対するパルス磁気刺激の効果
  • シンフゼン ニ トモナウ コッカクキン ノ ソクキンカ ト ミトコンドリア キノウ ショウガイ ニ タイスル パルス ジキ シゲキ ノ コウカ

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Abstract

<p>The purpose of the study was to verify the effects of pulsed magnetic stimulation on the skeletal muscle mitochondrial dysfunction associated with heart failure. Wistar rats were divided into three groups; control, heart failure (HF), and heart failure plus pulsed magnetic stimulation groups (HF+MS). Right heart failure was induced in the HF and HF+MS groups via monocrotaline injection. The right ventricular mass and pulmonary arterial wall thickness increased in the HF and HF+MS groups. In addition, the level of oxidative stress increased, and the composition ratio of slow twitch fiber, the activity of mitochondrial enzyme and the expression level of PGC-1α protein decreased in the soleus muscle of the HF group. Meanwhile, pulsed magnetic stimulation attenuated decreases in the composition ratio of slow twitch fiber and mitochondrial function in skeletal muscle. These results suggest that pulsed magnetic stimulation could prevent skeletal muscle dysfunction associated with heart failure without deteriorating cardiopulmonary tissues.</p>

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