Metabolism-related and cytokine-related gene expression and pancreatic pathology of a Japanese Black breeding cow with severe fat necrosis

DOI JASI Web Site Web Site 17 References
  • Kojima H.
    Nagasaki Prefecture Agricultural Mutual Aid Association
  • Tani C.
    Platinum Veterinary Service
  • Tomokawa K.
    Nagasaki Prefecture Agricultural Mutual Aid Association
  • Igasaki D.
    Nagasaki Prefecture Agricultural Mutual Aid Association
  • Ohashi Y.
    Veterinarian Anatomy Course, Department of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki
  • Yasuda M.
    Veterinarian Anatomy Course, Department of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki

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Other Title
  • 重度の脂肪壊死症を認めた黒毛和種繁殖牛における病変部の脂肪代謝関連とサイトカイン関連の遺伝子発現と膵臓の病理所見
  • ジュウド ノ シボウ エシショウ オ ミトメタ クロゲワシュ ハンショクギュウ ニ オケル ビョウヘンブ ノ シボウ タイシャ カンレン ト サイトカイン カンレン ノ イデンシ ハツゲン ト スイゾウ ノ ビョウリ ショケン

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Abstract

<p>　A 63-month-old, Japanese black breeding cow at 223 days of gestation was presented for chief complaints of anorexia and mild straining. At initial presentation, the tail was raised, and frequent, small amounts of muddy diarrhea were observed. On rectal examination, a hard mass was palpated at about 25 cm cranial to the anus, and rectal stricture to the size of one finger was also noted. From the symptoms and rectal examination findings, fat necrosis was suspected. Isoprothiolane was administered for 1 month. At 283 day of gestation, the cow exhibited signs of labor pains and had veterinarian-assisted vaginal delivery. Post-calving, the cow continued to have anorexia and dyschezia but nursed the calf successfully. Approximately 3 months after calving, the calf was weaned, and the cow was culled due to poor prognosis.</p><p>　Necropsy revealed a white-yellow, saponified necrotic fat mass （15 cm × 30 cm） surrounding the rectum. Two other necrotic fatty masses（about 15 cm × 15 cm） were also noted in the mesentery of the spiral colon. In the pancreas, no macroscopic lesions were present, but extensive fat infiltration was noted within the parenchyma by histological examination. The mRNA expressions of PPAR-γ and TNF-α were higher in the abdominal fat necrotic lesions compared to the normal adipose tissue, indicating an inflammatory process and suppressed adipocyte hypertrophy.</p>

Journal

  • Japanese Journal of Large Animal Clinics

    Japanese Journal of Large Animal Clinics 11 (5), 204-209, 2020-12-31

    Japanese Society of Large Animal Clinics / Large Animal Clinic Research Association / Kyushu-Okinawa Society for Large Animal Medicine

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