Cerebellar cortical degeneration with increased phosphorylated neurofilament heavy chain in cerebrospinal fluid in a Holstein calf

DOI JASI Web Site Web Site 17 References
  • Kawakami Y.
    Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
  • Uesaka K.
    United Graduate School of Veterinary Sciences, Gifu University
  • Hiasa J.
    Veterinary Clinical Division, Shihoro Agricultural Cooperative Association
  • Nakagun S.
    United Graduate School of Veterinary Sciences, Gifu University
  • Kobayashi Y.
    Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine United Graduate School of Veterinary Sciences, Gifu University
  • Inokuma H.
    Veterinary Medical Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo

Bibliographic Information

Other Title
  • 脳脊髄液中リン酸化ニューロフィラメント重鎖濃度の上昇を認めたホルスタイン種子牛の小脳皮質変性症の1 症例
  • ノウ セキズイエキ チュウ リンサンカ ニューロフィラメント ジュウサ ノウド ノ ジョウショウ オ ミトメタ ホルスタイン シュシギュウ ノ ショウノウ ヒシツ ヘンセイショウ ノ 1 ショウレイ

Search this article

Abstract

<p>　A 115-day-old Holstein heifer was presented to a local veterinarian for evaluation of abnormal gait. At 122 days old, the heifer was able to stand but had a wide stance, hypermetria, stiff gait, falling, lateral recumbency and opisthotonos. In the following two weeks, the heifer remained recumbent for increasingly longer times, having difficulty in standing and walking. Bilateral nystagmus was also observed. Necropsy revealed no obvious gross abnormalities in the central nervous system, but loss of Purkinje cells and axonal swelling in the cerebellar cortex as well as vacuoles in the molecular layer were noted by histological examination. Cerebellar cortical degeneration was diagnosed based on these findings. Although the biochemical profile of the cerebrospinal fluid was unremarkable, the cerebrospinal fluid concentration of phosphorylated neurofilament heavy chain（pNF-H） was 597.7 pg/mℓ, which was higher than the median value of 294.7 pg/mℓ in five clinically healthy Holstein calves. The pNF-H level may be used as a prognostic marker for neuronal injury.</p>

Journal

  • Japanese Journal of Large Animal Clinics

    Japanese Journal of Large Animal Clinics 11 (5), 198-203, 2020-12-31

    Japanese Society of Large Animal Clinics / Large Animal Clinic Research Association / Kyushu-Okinawa Society for Large Animal Medicine

References(17)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top