Development of Synthetic Molecules with Protein Like Functions

DOI Web Site 12 References
  • SATO Kohei
    School of Life Science and Technology, Tokyo Institute of Technology
  • KINBARA Kazushi
    School of Life Science and Technology, Tokyo Institute of Technology

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Other Title
  • 生体分子機能を有する新物質への有機合成化学によるアプローチ

Abstract

<p>Inspired by the structure and dynamic functions of transmembrane proteins, we have developed a series of multiblock molecules having an alternating sequence of hydrophobic and hydrophilic domains. These amphiphilic molecules form unimolecular or supramolecular ion channels in lipid bilayer membranes, with responsiveness to external stimuli, such as osmotic pressure (tension), ligand addition, and electric fields. In addition, the molecules bearing phosphate ester groups allow directional control of molecular alignments in the membranes. This feature has great advantages for future applications in biological, medicinal and materials sciences.</p>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 62 (4), 219-223, 2022

    The Biophysical Society of Japan General Incorporated Association

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