The role of dorpaminergic neurotransmission via D1 and D2 receptors in motor control and aversive memory formation.
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- Saito Nae
- Brain Research Institute, Niigata University
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- Itakura Makoto
- Kitasato University, School of Medicine
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- Tainaka Kazuki
- Brain Research Institute, Niigata University
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- Macpherson Tom
- Institute for Protein Research, Osaka University
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- Hikida Takatoshi
- Institute for Protein Research, Osaka University
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- Yamaguchi Shun
- Graduate School of Medicine, Gifu University
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- Sato Asako
- Kitasato University, School of Medicine
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- Okubo Tadashi
- Kitasato University, School of Medicine
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- Chiken Satomi
- National Institute for Physiological Sciences
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- Nambu Atsushi
- National Institute for Physiological Sciences
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- Sasaoka Toshikuni
- Brain Research Institute, Niigata University
Bibliographic Information
- Other Title
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- D1およびD2ドーパミン受容体を介する神経伝達による運動制御と学習記憶の仕組みの理解
Abstract
Dopaminergic neurotransmission is considered to play a wide range of important roles in such as motor control, cognition, motivation, learning, and memory. Dopamine activates the direct pathway via the D1 receptor (D1R) and suppresses the indirect pathway via the D2 receptor (D2R) in the basal ganglia circuit. To clarify D1R or D2R‐mediated dopaminergic neurotransmission in more detail, we investigated the role of dopaminergic neurotransmission via dopamine D1Rs in motor function and aversive memory formation using conditional D1R knockdown (D1RcKD) mice, in which the expression of D1Rs can conditionally and reversibly be controlled by doxycycline treatment. It was revealed that dopaminergic neurotransmission via dopamine D1Rs maintains information transmission of the direct pathway of the basal ganglia circuit and promotes motor function. Furthermore, our findings indicated that D1R‐mediated dopaminergic transmission is critical for aversive memory formation, specifically by influencing Arc expression in the cerebral cortex. Here, we mainly present motor control and aversive memory formation using D1RcKD mice, including our recent findings.
Journal
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- Japanese Journal of Biological Psychiatry
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Japanese Journal of Biological Psychiatry 33 (3), 100-105, 2022
Japanese Society of Biological Psychiatry
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Details 詳細情報について
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- CRID
- 1390293556142264064
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- ISSN
- 21866465
- 21866619
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- Text Lang
- ja
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- Data Source
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- JaLC
- KAKEN
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- Abstract License Flag
- Disallowed