Baroreflex Sensitivity with Atrial Fibrillation

Miyoshi Miho, Kondo Hidekazu, Takahashi Naohiko

doi:10.5105/jse.42.131

<p>【Background】It has been reported that atrial fibrillation（AF）may contribute to impairment of baroreflex sensitivity（BRS）. However, the difference of BRS between patients with persistent AF（PeAF）and those with paroxysmal AF（PAF）is unknown. We tested the hypothesis that patients with PeAF have a more impaired BRS compared with those with PAF.【Methods and Results】From October 2015 onwards, a total of 67 patients（14 women［20.9%］；mean age 65.2±10.1 years）with PAF（n＝46, 68.7%）and PeAF（n＝21, 31.3%）, who underwent catheter ablation, were prospectively enrolled. The baseline BRS was evaluated during sinus rhythm. Baseline BRS in patients with PeAF was significantly lower than those with PAF（2.97［0.52-6.62］ms/mmHg versus 4.70［2.36-8.37］ms/mmHg, P＝0.047）. BRS was significantly depressed after catheter ablation in all patients（4.66 ［1.80-7.37］ms/mmHg versus 0.55［−0.15 to 1.22］ms/mmHg, P＜0.001）. However, the depression of BRS because of catheter ablation appeared more attenuated in patients with PeAF compared with those with PAF. The difference of BRS before and after ablation in patients without recurrence was significantly greater than those in patients with recurrence in PAF group.【Conclusions】Our findings demonstrated that baseline BRS was more depressed in patients with PeAF compared with PAF. Catheter ablation depressed BRS irrespective of the type of AF, with a greater effect in patients with PAF than PeAF.</p>

Baroreflex Sensitivity with Atrial Fibrillation

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