Reconsideration of the optimal reactive hyperemia index for predicting cardiovascular events in Japanese population

DOI Web Site
  • AKAMINE Satomi
    Central Clinical Laboratory, The Jikei University Daisan Hospital
  • SHIBATA Kanako
    Central Clinical Laboratory, The Jikei University Daisan Hospital
  • TORIZUKA Junko
    Central Clinical Laboratory, The Jikei University Daisan Hospital
  • SHIMOJO Ayako
    Central Clinical Laboratory, The Jikei University Daisan Hospital
  • HOSHINO Yoko
    Central Clinical Laboratory, The Jikei University Daisan Hospital
  • ABE Masaki
    Central Clinical Laboratory, The Jikei University Daisan Hospital
  • NAKADA Koji
    Central Clinical Laboratory, The Jikei University Daisan Hospital
  • SHIBATA Takahiro
    Department of Cardiology, The Jikei University Daisan Hospital

Bibliographic Information

Other Title
  • 日本人に適したreactive hyperemia indexの心血管イベント予測値を再考する
  • ニホンジン ニ テキシタ reactive hyperemia index ノ シンケッカン イベント ヨソクチ オ サイコウ スル

Search this article

Abstract

<p>Endothelial dysfunction has been reported to predict future cardiovascular events. Reactive hyperemia index measurement is a noninvasive index of predicting endothelial dysfunction. A reactive hyperemia index of less than 1.67 is usually considered to indicate endothelial dysfunction. However, this value is based on the results of Westerners. In this study, we measured the reactive hyperemia index in 173 patients and then followed them up for 42 ± 11 months. Twenty-two cardiovascular events occurred during the follow-up period. The patients were divided into two groups on the basis of the reactive hyperemia index cutoff value of 1.67, which is commonly used to predict endothelial dysfunction. There was no significant difference in the incidence of coronary risk factors such as hypertension and diabetes as well as cardiovascular events between the two groups. The reactive hyperemia index, which well predicts cardiovascular events and is obtained from the receiver operating characteristic curve, was less than 1.98 in this study. The incidence of cardiovascular events was significantly different between groups divided on the basis of a cutoff value of 1.98. Although a cutoff value of 1.67 has been commonly applied to predict cardiovascular events in Westerners, a higher cutoff value of 1.98 may be appropriate for the Japanese population.</p>

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top