Light-responsive RNA delivery

DOI Web Site 37 References Open Access
  • Watanabe Kazunori
    Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
  • Ohtsuki Takashi
    Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University

Bibliographic Information

Other Title
  • 光応答的なRNAデリバリー

Abstract

Nucleic acid drugs, such as mRNA and siRNA, have recently been attracting attention, and are promising as drugs that will support the next generation of medicine. For RNA, to act specifically at the target site as a medicine, an efficient method of RNA delivery into the target cells is important. In this review, we focus on target-specific RNA delivery using light, which is one of the various targeting strategies. Specifically, we discuss the use of carriers that deliver RNAs into the cytoplasm via photochemical internalization （PCI） or photothermal mechanisms. These carriers facilitate RNA delivery into the cytoplasm only in target cells irradiated with light, allowing RNA drugs to act target-specifically. Although this special issue is focused on mRNA therapeutics, there are very few reports on light-responsive mRNA delivery. In contrast, there are many reports of light-responsive delivery of small RNA, such as siRNA and miRNA. Thus, this review focuses on examples of small-RNA delivery systems that will be diverted to mRNA delivery in the near future. A few examples of light-responsive mRNA delivery are also described.

Journal

  • Drug Delivery System

    Drug Delivery System 37 (3), 229-236, 2022-07-25

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

References(37)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top