A case of crescentic glomerulonephritis and acute tubulointerstitial nephritis requiring temporary hemodialysis during nivolumab treatment for renal cell carcinoma
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- Uwatoko Ryuta
- Department of Nephrology and Hypertension, Osaka General Medical Center
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- Kani Nao
- Department of Nephrology and Hypertension, Osaka General Medical Center
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- Makino Syuzo
- Department of Nephrology and Hypertension, Osaka General Medical Center
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- Naka Tomoya
- Department of Nephrology and Hypertension, Osaka General Medical Center
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- Okamoto Kazuhiro
- Department of Nephrology and Hypertension, Osaka General Medical Center
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- Miyakawa Hiromitsu
- Department of Nephrology and Hypertension, Osaka General Medical Center
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- Hashimoto Nobuhiro
- Department of Nephrology and Hypertension, Osaka General Medical Center
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- Iio Rei
- Department of Nephrology and Hypertension, Osaka General Medical Center
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- Ueda Yoshiyasu
- Department of Nephrology and Hypertension, Osaka General Medical Center
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- Hayashi Terumasa
- Department of Nephrology and Hypertension, Osaka General Medical Center
Bibliographic Information
- Other Title
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- 腎細胞癌に対してニボルマブ投与中に半月体形成性糸球体腎炎ならびに急性尿細管間質性腎炎をきたし一時的に血液透析を要した1 例
- ジンサイボウガン ニ タイシテ ニボルマブ トウヨ チュウ ニ ハンツキタイ ケイセイセイ シキュウタイジンエン ナラビニ キュウセイ ニョウ サイカン カンシツセイジンエン オ キタシ イチジテキ ニ ケツエキ トウセキ オ ヨウシタ 1レイ
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Description
<p>A 76-year-old male underwent left nephrectomy for left renal cell carcinoma in July X-3. In July X-2, metastasis to the left crus of the diaphragm was confirmed. He was treated with pazopanib and axitinib, but the disease progressed. He was treated with heavy particle irradiation. However, in February X metastasis was detected in the upper lobe of the right lung, and he was started on nivolumab. Before the start of the nivolumab treatment, he had a serum creatinine level (S-Cr) of 1.52 mg/dL, and urinary tests produced the following results:urinary protein (–) and urinary occult blood (–). He received 240 mg nivolumab every 2 weeks for a total of 4 doses. After that, his S-Cr increased to 3.6 mg/dL. He was referred to our department and admitted in June X. On the 8th day, a renal biopsy was performed. Crescentic glomerulonephritis and acute tubulointerstitial nephritis were diagnosed. Steroid therapy was started on the 12th day. Although he needed hemodialysis for 2 weeks, he achieved a partial renal recovery. As crescentic glomerulonephritis caused by immune checkpoint inhibitors is rare, further case accumulation is needed.</p>
Journal
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- Nihon Toseki Igakkai Zasshi
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Nihon Toseki Igakkai Zasshi 55 (10), 595-601, 2022
The Japanese Society for Dialysis Therapy
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Details 詳細情報について
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- CRID
- 1390293898800273152
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- NII Book ID
- AN10432053
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- ISSN
- 1883082X
- 13403451
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- NDL BIB ID
- 032499279
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
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- Abstract License Flag
- Disallowed