Glycan analysis of salivary gland tumor; Mucoepidermoid carcinoma and tumor associated MUC1

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  • Isaka Eisaku
    Department of Oral Rehabilitation and Maxillofacial Surgery, School of Medicine, International University of Health and Welfare, Chiba, Japan
  • Sugiura Takanori
    Department of Oral Oncology, Oral and Maxillofacial Surgery, Tokyo Dental College, Chiba, Japan
  • Hashimoto Kazuhiko
    Department of Pathology and Laboratory Medicine, Ichikawa General Hospital, Tokyo Dental College, Chiba, Japan
  • Kikuta Kazutaka
    Department of Musculoskeletal Oncology and Orthopaedic Surgery, Tochigi Cancer Center, Tochigi, Japan
  • Anazawa Ukei
    Department of Orthopaedic Surgery
  • Nomura Takeshi
    Department of Oral Oncology, Oral and Maxillofacial Surgery, Tokyo Dental College, Chiba, Japan
  • Kameyama Akihiko
    Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan

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Other Title
  • 唾液腺腫瘍の糖鎖解析―粘表皮癌と腫瘍関連MUC1―

Abstract

<p>Mucoepidermoid carcinoma is one of the typical salivary gland malignancies rich in mucin. Mucin1 (MUC1) has been researching for a long ago as a tumor marker for determining diagnosis and prognosis, and moreover O-glycans are changed with malignancy. We performed O-glycans analysis of mucin expression in mucoepidermoid carcinoma and normal salivary glands using supported molecular matrix electrophoresis (SMME). As a result, the core 2 type glycans, (Hex)2(HexNAc)2(NeuAc)1 and (Hex)2(HexNAc)2(NeuAc)2, were found to be significantly abundant glycans of MUC1 in Mucoepidermoid carcinoma. This time, we will report on these series of studies.</p>

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