Development of Specific PET Tracers for Central Nervous System Drug Targets
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- 小池 竜樹
- 武田薬品工業株式会社
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<p>The development of biomarkers is key to the discovery of novel drugs. Positron emission tomography (PET) tracers are powerful noninvasive neuroimaging biomarkers which enable to monitor the target engagement of the central nervous system (CNS) drugs. This report describes the design, synthesis, and identification of specific PET tracers for CNS drug targets, namely, monoacylglycerol lipase ([18F]T-401), diacylglycerol kinase gamma ([11C]T-278), lysine-specific demethylase 1 ([18F]T-914) and cholesterol 24-hydroxylase ([18F]T-008), based on screening flow customized for PET tracer discovery. Analyzing PET images of rodents and non-human primates confirmed that these tracers could serve as biomarkers to support the development of novel drugs.</p>
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 80 (11), 1044-1054, 2022-11-01
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390294020636103680
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- NII書誌ID
- AN0024521X
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 032517206
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 使用不可