Usefulness in Nasogastric Tube Blockage by Addition of Food Thickener to Suspension of Depakene<sup>®</sup> Fine Granules 40%

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  • Hamada Shigeaki
    Department of Pharmacy, Japanese Red Cross Tokushima Hinomine Rehabilitation Center for People with Disabilities
  • Morimoto Masahito
    Department of Pharmacy, Japanese Red Cross Tokushima Hinomine Rehabilitation Center for People with Disabilities
  • Ohshima Naomi
    Nursing Division, Japanese Red Cross Tokushima Hinomine Rehabilitation Center for People with Disabilities
  • Shinohara Yukiko
    Nursing Division, Japanese Red Cross Tokushima Hinomine Rehabilitation Center for People with Disabilities
  • Suzue Tomoko
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University
  • Ishida Shiro
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University

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  • デパケン<sup>®</sup>細粒40％懸濁液の経鼻栄養チューブ閉塞に対するとろみ調整食品添加の有用性

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<p>Depakene® fine granules (Depakene) that contain 40％ sodium valproate have a high sedimentation rate and poor suspension dispersibility. Administration of Depakene suspension via a commonly used nasal 8-Fr outer diameter feeding tube results in tube blockage. The study aimed to determine if the addition of thickened food to Depakene would prevent tube blockage observed with Depakene suspension alone. We tested a 1 g / 20 mL Depakene suspension with the addition of various concentrations of thickened food and measured the dissolution profile and tube passage amounts of sodium valproate. When the concentrations of thickened food were ≤ 2％, the dissolution profile and tube passage amount of sodium valproate were not affected. In a questionnaire survey on the sensation of injecting the Depakene suspension into a tube, most respondents said that a 0.38％ thickened food concentration was the “easiest to inject,” with infrequent tube blockages. Since the plunger pressing force for the 0.38％ thickened food concentration was about 12 N, it was regarded as the load that an adult woman could easily inject into the tube. To summarize, we found that a thickened food concentration of 0.38％ effectively prevented tube blockage of a 1 g / 20 mL suspension of Depakene.</p>

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