Association of Kidney Function with Serum Levels of Cholesterol Absorption and Synthesis Markers: The CACHE Study CKD Analysis

DOI Web Site PubMed 6 Citations 41 References Open Access
  • Shoji Tetsuo
    Department of Vascular Medicine, Osaka City University Graduate School of Medicine Vascular Science Center for Translational Research, Osaka City University Graduate School of Medicine
  • Akiyama Yusuke
    Division of Cardiovascular Medicine, Oita Prefectural Hospital
  • Fujii Hisako
    Department of Health and Medical Innovation, Osaka City University Graduate School of Medicine
  • Harada-Shiba Mariko
    Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute
  • Ishibashi Yutaka
    Department of General Medicine, Shimane University Faculty of Medicine Jinjukai Education & Training Center for Healthcare Professionals
  • Ishida Tatsuro
    Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine
  • Ishigaki Yasushi
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University
  • Kabata Daijiro
    Department of Medical Statistics, Osaka City University Graduate School of Medicine
  • Kihara Yasuki
    Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Kotani Kazuhiko
    Division of Community and Family Medicine, Jichi Medical University
  • Kurisu Satoshi
    Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Masuda Daisaku
    Rinku General Medical Center
  • Matoba Tetsuya
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
  • Matsuki Kota
    Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
  • Matsumura Takeshi
    Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University
  • Mori Kenta
    Department of General Internal Medicine, Kobe University Hospital
  • Nakagami Tomoko
    Division of Diabetology and Metabolism, Department of Internal Medicine, Tokyo Women’s Medical University School of Medicine
  • Nakazato Masamitsu
    Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki
  • Taniuchi Satsuki
    Department of Medical Statistics, Osaka City University Graduate School of Medicine
  • Ueno Hiroaki
    Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki
  • Yamashita Shizuya
    Rinku General Medical Center
  • Yoshida Hisako
    Department of Medical Statistics, Osaka City University Graduate School of Medicine
  • Yoshida Hiroshi
    Department of Laboratory Medicine, The Jikei University Kashiwa Hospital, Kashiwa

Search this article

Description

<p> Aim: Serum levels of cholesterol absorption and synthesis markers are known to be associated with cardiovascular risk. Individuals with reduced kidney function or chronic kidney disease (CKD) are at an increased risk for cardiovascular disease. Hence, we examined the relationship between estimated glomerular filtration rate (eGFR) and serum markers of cholesterol absorption and synthesis.</p><p>Methods: The CACHE (Cholesterol Absorption and Cholesterol synthesis in High-risk patiEnts) Consortium, comprised of 13 research groups in Japan possessing data of lathosterol (Latho, synthesis marker) and campesterol (Campe, absorption marker) measured via gas chromatography, compiled the clinical data using the REDCap system. Among the 3597 records, data from 2944 individuals were utilized for five analyses including this CKD analysis.</p><p>Results: This study analyzed data from 2200 individuals including 522 hemodialysis patients; 42.3% were female, the median age was 58 years, and the median eGFR was 68.9 mL/min/1.73 m2. Latho, Campe, and Campe/Latho ratio were significantly different when compared across CKD stages. When the associations of eGFR with these markers were assessed with multivariable nonlinear regression models, Latho, Campe, and Campe/Latho ratio showed positive, inverse, and inverse associations with eGFR. These associations were significantly modified by sex, the presence/absence of diabetes mellitus, and the presence/absence of statin use.</p><p>Conclusion: We showed that individuals with lower eGFR have lower cholesterol synthesis marker levels and higher cholesterol absorption marker levels in this large sample.</p>

Journal

Citations (6)*help

See more

References(41)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top