Evaluation of Patients with Localized Prostate Cancer in whom Long-Term Successful Androgen Deprivation Therapy was Ceased

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  • ARAKI Hiromasa
    The Department of Urology, National Hospital Organization Kyoto Medical Center
  • ITO Katsuhiro
    The Department of Urology, Graduate School of Medicine, Kyoto University
  • IGARASHI Atsushi
    The Department of Urology, National Hospital Organization Kyoto Medical Center
  • MIURA Takayoshi
    The Department of Urology, National Hospital Organization Kyoto Medical Center
  • MIYAZAKI Yu
    The Department of Urology, National Hospital Organization Kyoto Medical Center
  • MISHINA Mutsuki
    The Department of Urology, National Hospital Organization Kyoto Medical Center
  • OKUNO Hiroshi
    The Department of Urology, National Hospital Organization Kyoto Medical Center

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Other Title
  • 長期制癌にてアンドロゲン遮断療法を中止した限局性前立腺癌症例の検討
  • チョウキ セイガン ニテ アンド ロゲン シャダン リョウホウ オ チュウシ シタ ゲンキョクセイ ゼンリツセンガン ショウレイ ノ ケントウ

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Abstract

We evaluated the clinical course of patients with localized prostate cancer in whom long-term successful androgen deprivation therapy (ADT) was ceased. Study subjects were 24 patients with stage B prostate cancer who were initially treated with ADT for a median duration of 93 months. The median age at the cessation of ADT was 84 years. The median nadir serum prostate specific antigen (PSA) level was 0.022 ng/ml. The median duration of follow-up from the cessation of ADT was 31 months. During follow-up, five patients showed PSA elevation of ≥2 ng/ml from the nadir. Serum testosterone level was tested in 20 patients, and five showed testosterone recovery ≥0.5 ng/ml. Seven patients died from diseases other than prostate cancer, but there were no deaths caused by prostate cancer. This study demonstrated that long-term successful ADT for localized prostate cancer could be ceased with adequate follow-up evaluation.

Journal

  • 泌尿器科紀要

    泌尿器科紀要 68 (11), 337-343, 2022-11-30

    泌尿器科紀要刊行会

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