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- 神谷 真子
- 東京工業大学・生命理工学院・生命理工学系
書誌事項
- タイトル別名
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- Activatable fluorescence probes for rapid cancer imaging
抄録
<p>It has been a long-term goal to develop cancer-imaging techniques that have sufficient specificity and sensitivity, since early detection and complete resection are an important prognosticator for cancer treatment. Since fluorescence-guided diagnosis is one of the most powerful techniques for real-time in situ cancer detection, we have focused on developing a cancer-imaging method with activatable fluorescent probes targeted to enzymes that are overexpressed in cancer. These include probes for cancer-associated aminopeptidases, carboxypeptidases, and glycosidases, which allowed us to visualize certain types of cancers in the resected clinical specimens from the patients. In this presentation, I would like to introduce the molecular design, our recent effort for screening the candidate probes from our probe library, and its application for clinical specimens. We hope that fluorescence-guided diagnosis by our activatable probes can be used as an imaging guidance during surgical procedures to help surgeons for efficient tumor inspection.</p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 96 (0), 2-B-S14-3-, 2022
公益社団法人 日本薬理学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390294562485772032
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- ISSN
- 24354953
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可