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- 莚田 泰誠
- 理研・生命医科学研究センター・ファーマコゲノミクス研究チーム
書誌事項
- タイトル別名
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- Pharmacogenetic testing for prevention of severe cutaneous adverse drug reactions
抄録
<p>Adverse drug reactions (ADRs) such as skin rash, drug-induced liver injury, and agranulocytosis have long been analyzed in relation to human leukocyte antigen (HLA) that is an important molecule involved in human immunity. HLA is composed of many genes, each of which has dozens of different types (alleles), and many HLA alleles associated with ADRs have been reported, starting with the report of HLA-DRB1*08:03:02 associated with agranulocytosis by methimazole. The odds ratios in the association with HLA alleles range from approximately 5 to several thousand, indicating a very large impact on the risk of ADRs. Thus, HLA genetic testing prior to initiation of drug therapy is expected to make a significant contribution to avoiding ADRs, but to demonstrate the clinical utility of genetic testing, it is necessary to prospectively show the effects of medical interventions based on the test results. We conducted the GENCAT study, a prospective, multicenter, single-arm clinical trial to investigate the impact of a therapeutic intervention based on the HLA-A*31:01 test on the incidence of carbamazepine-induced skin rash. HLA-A*31:01-positive patients were treated with an alternative drug such as valproic acid, and the study showed an approximately 60% reduction in the incidence of carbamazepine-induced skin rash. It is expected that the genetic test, which has demonstrated clinical utility, will lead to the establishment of safer and more appropriate stratified medicine by reflecting the information in clinical practice guidelines.</p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 96 (0), 3-B-S28-3-, 2022
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390294562485875456
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- ISSN
- 24354953
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可