脳分子を回収して帰還する「はやぶさ型ナノマシン」の開発

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  • Development of "Hayabusa-type Nanomachine"

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<p>The nano-structured systems that transport bioactive substances to a target location in the body have recently attracted much attention and have been rapidly advancing. However, none of these systems have been able to efficiently enter the brain via a systemic route. Taking advantage of the phenomenon that GLUT1, which is expressed at a high level in the BCECs, migrates from the luminal to the abluminal side in response to an increase of blood glucose concentration from the hypoglycemic state, we succeeded in accumulating a self-assembled nanomachine with glucose integrated on the surface with optimal configuration in the brain, with significant efficiency. </p><p>In this presentation, I firstly will introduce the development of BBB-crossing Nanomachine. I will also introduce the results of nanomachines that efficiently pass through nucleic acid and antibody drugs into the brain using this system as a platform. And finally, the concept of a "Hayabusa-type Nanomachine," inspired by the planetary probe Hayabusa, which efficiently passes through the BBB, samples molecules in the brain, and returns them to the bloodstream to provide information on brain pathology, will be introduced.</p>

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