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- Kaminuma Osamu
- RIRBM, Hiroshima Univ.
Bibliographic Information
- Other Title
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- 新規アレルギー疾患モデルの開発を通じた次世代型機能性細胞デリバリーシステムの考案
Abstract
<p>The development of chimeric antigen receptor (CAR) T-cell therapies has been opening a new era in cell-based immunotherapy. However, like classical medicine-based therapies, efficiency of functional cell delivery toward target organs and cells is crucial for producing beneficial and adverse-effects of the cell-based therapy. To explore the pathogenesis of allergy diseases, we have been developing new mouse models of allergic inflammation, especially focusing the role of antigen-specific T cells. Antigen administration to mice transferred with in vitro-differentiated antigen-specific T cells evokes inflammatory responses at the site of antigen exposure. In response to chemokines produced and with the usage of several cell adhesion molecules upregulated, allergen-specific T cells efficiently recruit and proliferate in the inflammation sites. T cell has capacity to obtain various immune-regulatory properties following in vitro culture under specific conditions. Large number of T cells expressing T cell receptors reactive to specific antigens can be prepared by employing somatic cell nuclear transfer techniques. I would like to provide these data probably helpful for considering new cell delivery system in cell-based immunotherapy.</p>
Journal
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- Proceedings for Annual Meeting of The Japanese Pharmacological Society
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Proceedings for Annual Meeting of The Japanese Pharmacological Society 96 (0), 4-B-S35-2-, 2022
Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390294562485997952
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- ISSN
- 24354953
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
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- Abstract License Flag
- Disallowed