大脳皮質基底核変性症：臨床診断をめぐる問題点

林 祐一, 下畑 享良

doi:10.15082/jsnt.39.4_465

書誌事項

タイトル別名

Difficulties in the clinical diagnosis of corticobasal degeneration

説明

<p>The clinical diagnosis of corticobasal degeneration (CBD) is challenged by the existence of various phenotypes of CBD except corticobasal syndrome (CBS), CBD mimics, and immune–related CBS. Previously, 37% of the pathologically–verified CBD cases only had CBS, while the others presented progressive supranuclear palsy (PSP) syndrome, frontotemporal dementia (FTD), Alzheimer disease (AD)–like dementia or aphasia. Moreover, another report showed that 46% of CBS or CBD cases diagnosed by the clinical criteria were CBD mimics, which includes PSP, AD, FTD, globular glial tauopathy, prion disease, and other tauopathies. Recently, an anti–IgLON5 antibody related disease mimicking CBS was reported. The patient's symptoms were consistent for probable CBS ; however, some clinical and radiological findings were partially improved by immunotherapy. Therefore, the clinicians should be aware that such an anti–IgLON5 antibody related disease exists as a differentiated CBS, and more accurate clinical diagnostic criteria for CBD should be established.</p>

収録刊行物

神経治療学

神経治療学 39 (4), 465-467, 2022

日本神経治療学会

キーワード

詳細情報詳細情報について

CRID: 1390294562487929856

DOI: 10.15082/jsnt.39.4_465

ISSN: 21897824; 09168443

本文言語コード: ja

データソース種別

JaLC

抄録ライセンスフラグ: 使用不可

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