Muscle Biopsy-proven Drug-induced Microscopic Polyangiitis in a Patient with Tuberculosis

  • Kuwabara Gaku
    Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Japan
  • Yamada Koichi
    Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan
  • Tanaka Kiyomi
    Post Graduate Medical Training Center, Osaka City University Hospital, Japan
  • Nozuchi Satoshi
    Department of Neurology, Graduate School of Medicine, Osaka City University, Japan
  • Imoto Waki
    Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan
  • Shibata Wataru
    Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan
  • Tohda Mitsunori
    Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Japan
  • Kyoh Shigenori
    Department of Respiratory Medicine, Wakakusa-Daiichi Hospital, Japan
  • Itoh Yoshiaki
    Department of Neurology, Graduate School of Medicine, Osaka City University, Japan
  • Hashimoto Motomu
    Department of Clinical Immunology, Graduate School of Medicine, Osaka City University, Japan
  • Kakeya Hiroshi
    Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Japan

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抄録

<p>We herein report a case of muscle biopsy-proven microscopic polyangiitis (MPA) in a patient with tuberculosis. The patient had developed a persistent fever after the initiation of treatment for tuberculosis and was positive for myeloperoxidase-antineutrophil cytoplasmic antibody (ANCA). However, because conventional symptoms were lacking, determination of the biopsy site was difficult. Based on the findings of a biopsy of the biceps femoris, which confirmed small vessel vasculitis, the patient was diagnosed with MPA. The fever was alleviated by glucocorticoids. Tuberculosis and antituberculosis drugs can cause ANCA-associated vasculitis (AAV). A muscle biopsy is useful for the diagnosis of AAV. </p>

収録刊行物

  • Internal Medicine

    Internal Medicine 62 (1), 129-133, 2023-01-01

    一般社団法人 日本内科学会

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