Comparison of four different methods for thyroid-related tests: TSH, FT4, and FT3

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  • KASAHARA Yuko
    Department of Clinical Laboratory, The University of Tokyo Hospital
  • ISHIHARA Yuri
    Department of Clinical Laboratory, The University of Tokyo Hospital
  • SHIMOSAKA Hironori
    IMSUT Hospital, The Institute of Medical Science, The University of Tokyo
  • YOSHIKAWA Naoyuki
    Department of Clinical Laboratory, The University of Tokyo Hospital
  • ONO Yoshikazu
    Department of Clinical Laboratory, The University of Tokyo Hospital
  • KURANO Makoto
    Department of Clinical Laboratory, The University of Tokyo Hospital
  • YATOMI Yutaka
    Department of Clinical Laboratory, The University of Tokyo Hospital
  • TOBITA Akiko
    Department of Clinical Laboratory, The University of Tokyo Hospital

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Other Title
  • 免疫血清項目の4社機器・試薬の比較―甲状腺関連検査項目：TSH，FT4，FT3―
  • メンエキ ケッセイ コウモク ノ 4シャ キキ ・ シヤク ノ ヒカク : コウジョウセン カンレン ケンサ コウモク:TSH,FT4,FT3

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Abstract

<p>The standardization of thyroid-related tests, such as TSH, FT4, and FT3, is clinically important since several guidelines for thyroid diseases recommend the therapeutic targets based on their absolute values. Since the thyroid-related tests are performed with an immunoassay, however, the absolute values are largely influenced by the analytical devices and reagents used for the assays. The International Federation of Clinical Chemistry and Laboratory Medicine Committee for Standardization of Thyroid Function Tests (IFCC C-STFT) promotes the standardization of FT4 and the harmonization of TSH, and the latter is now ongoing in Japan. However, at present, there are few reports comparing the absolute values yielded by multiple thyroid-related tests conducted simultaneously. In this study, we compared the precisions and correlations among four different methods, including those offered by Abbott, Siemens, Tosoh, and Fujirebio. We obtained favorable results on the precisions and correlations; however, we observed substantial discrepancies among the absolute values obtained by using different methods. These results suggest that harmonization especially on the absolute values is further required for thyroid-related tests in Japan.</p>

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