Effect of olive leaf extract on skeletal muscle in disuse-induced muscle atrophy model rats

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  • 廃用性筋萎縮モデル動物へのオリーブ葉抽出物投与の影響

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Abstract

<p>Olive leaf extract (OLE) is an important source of hydroxytyrosol. Its beneficial properties such as antioxidant and anti-inflammatory have been reported. However, the effect of OLE on skeletal muscle has not been clarified. Here we aimed to investigate the muscle changes with OLE in disuse-induced muscle atrophy model.</p><p>Male Wistar rats were divided into three groups, Non-casted, Casted, and OLE group. In the immobilized group, unilateral ankle joint was immobilized in full plantar flexion by a cast (Casted). During the experiment period, OLE was orally administrated at the dose of 100 mg/kg body weight to OLE group. After 2 weeks of hindlimb immobilization, soleus, plantar, gastrocnemius muscles were dissected. The level of muscle atrophy was assessed by muscle weight and cross-sectional area (CSA) of muscle fiber. No significant differences were observed between Casted group and OLE group in muscle weight, but the decrease of CSA of plantar muscle suppressed in OLE group.</p><p>The effect of OLE on muscle cells were studied in LPS-induced C2C12 myotubes. Treatment with OLE prevented the decrease in C2C12 myotube diameter caused by LPS stimulation. Our findings indicate that OLE may be involved in the improvement of disuse muscle atrophy.</p>

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