Quantitative analysis of cyclic prolyl-hydroxyproline in human plasma after ingestion of gelatin and gelatin hydrolysates

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  • Iwasaki Yu
    Graduate School of Humanities and Life Sciences, Tokyo Kasei University
  • Nakatogawa Mizuho
    Graduate School of Humanities and Life Sciences, Tokyo Kasei University
  • Sato Yoshio
    Graduate School of Humanities and Life Sciences, Tokyo Kasei University
  • Shigemura Yasutaka
    Graduate School of Humanities and Life Sciences, Tokyo Kasei University

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  • ゼラチンとコラーゲンペプチド摂取後の血液中環状ペプチドの定量

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<p>This study examined the changes in concentration of cyclic prolyl-hydroxyproline (cyclo(Pro-Hyp)) in human plasma after ingestion of gelatin, gelatin hydrolysate (collagen peptide; CP) and low-molecular weight CP. This human study showed that gelatin ingestion significantly increased cyclo (Pro-Hyp) levels in plasma from 1 hour after ingestion as well as CP and low-molecular weight CP. Furthermore, the ratio of cyclic Pro-Hyp to the total content of cyclic and liner Pro-Hyp in plasma after gelatin ingestion was highest among other CP ingestions. These results suggested that gelatin can be candidate for active components of the health benefits by gelatin and CP ingestion. In addition, in case of gelatin, large individual differences in cyclo (Pro-Hyp) concentration was observed in plasma at each time point after ingestion. It might indicates that cyclo (Pro-Hyp) concentration into plasma is affected not only molecular size of gelatin products, but also cyclization ability in each subjects. A further study for elucidating the mechanism of peptide cyclization in gastrointestinal tract is now in progress.</p>

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