Optimal Cut-off Points of Triglycerides for Cardiovascular Disease Prediction in Japanese Population

DOI DOI 機関リポジトリ 機関リポジトリ (HANDLE) Web Site ほか3件をすべて表示 一部だけ表示 被引用文献2件 参考文献38件 オープンアクセス
  • Imano Hironori
    Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Department of Public Health, Kindai University Faculty of Medicine Osaka Center for Cancer and Cardiovascular Disease Prevention
  • Li Jiaqi
    Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine
  • Tanaka Mari
    Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine
  • Yamagishi Kazumasa
    Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba Ibaraki Western Medical Center
  • Muraki Isao
    Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine
  • Umesawa Mitsumasa
    Department of Public Health, Dokkyo Medical University School of Medicine
  • Kiyama Masahiko
    Osaka Center for Cancer and Cardiovascular Disease Prevention
  • Kitamura Akihiko
    Yao Public Health Center, Yao City Office
  • Sato Shinichi
    Chiba Prefectural Institute of Public Health
  • Iso Hiroyasu
    Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Institute for Global Health Polycy Research (iGHP), National Center for Global Health and Medicine

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  • Optimal Cut-off Points of Nonfasting and Fasting Triglycerides for Prediction of Ischemic Heart Disease in Japanese General Population: The Circulatory Risk in Communities Study (CIRCS)

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<p> Aims: We investigated the optimal cut-off points of nonfasting and fasting triglycerides in Japanese individuals with lower average triglyceride levels than westerners.</p><p> Methods: Residents aged 40–69 years without a history of ischemic heart disease or stroke were enrolled between 1980 and 1994 and followed. Serum triglyceride concentrations were measured from 10851 nonfasting (＜8 h after meal) and 4057 fasting (≥ 8 h) samples. As a prerequisite, we confirmed the shape of a receiver operating characteristic (ROC) curves, the area under ROC curves (AUC), and the integrated time-dependent AUC. We identified optimal cut-off points for incident ischemic heart disease based on C-statistic, Youden index, and Harrell’s concordance statistic. We used dichotomized concentrations of triglycerides via the univariate logistic regression and Cox proportional hazards regression models. We also calculated multivariable hazard ratios and population attributable fractions to evaluate the optimal cut-off points.</p><p>Results: Nonfasting and fasting optimal cut-off points were 145 mg/dL and 110 mg/dL, with C-statistic of 0.594 and 0.626, Youden index of 0.187 and 0.252, and Harrell’s concordance statistic of 0.590 and 0.630, respectively. The corresponding multivariable hazard ratios of ischemic heart disease were 1.43 (95%CI 1.09–1.88) and 1.69 (1.03–2.77), and the corresponding population attributable fractions were 16.1% (95%CI 3.3–27.2%) and 24.6 (−0.3–43.3).</p><p>Conclusion: The optimal cut-off points of nonfasting and fasting triglycerides in the Japanese general population were 145 mg/dL and 110 mg/dL, respectively, lower than the current cut-off points recommended in the US and Europe.</p>

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