Periostin is an aggravating factor and predictive biomarker of eosinophilic chronic rhinosinusitis
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- Sato Teruyuki
- Division of Otolaryngology, Tohoku Medical and Pharmaceutical University
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- Ikeda Hiroki
- Department of Otolaryngology, Japanese Red Cross Wakayama Medical Center
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- Murakami Keigo
- Division of Pathology, Tohoku Medical and Pharmaceutical University
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- Murakami Kazuhiro
- Division of Pathology, Tohoku Medical and Pharmaceutical University
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- Shirane Shion
- Division of Otolaryngology, Tohoku Medical and Pharmaceutical University
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- Ohta Nobuo
- Division of Otolaryngology, Tohoku Medical and Pharmaceutical University
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<p>Background: Patients with eosinophilic chronic rhinosinusitis (ECRS) respond poorly to many treatment modalities. Overproduction of periostin in the nasal mucosa is reported to contribute to polyp formation. This study examined periostin levels in patients with ECRS in comparison with levels in patients with non-ECRS.</p><p>Methods: Fifty-nine patients with chronic rhinosinusitis were grouped into those with ECRS and those with non-ECRS. We compared the relationships between peripheral blood eosinophil level, serum periostin level, histopathological findings, clinical and laboratory findings, nose findings, diagnostic score of the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis Study, and postoperative recurrence of nasal polyps in each group.</p><p>Results: In the ECRS group, a positive correlation was found between peripheral blood eosinophil level and serum periostin level (rs = 0.49, P < 0.01: Spearman's rank correlation coefficient). ROC curve analysis was used to evaluate the serum periostin level that could predict postoperative recurrence of nasal polyps in the ECRS group: the area under the curve (AUC) was 0.95, sensitivity was 92%, and specificity was 100%; the serum periostin cutoff value for postoperative recurrence of nasal polyps was 130 ng/ml. In ROC curve analysis to evaluate peripheral blood eosinophil level, the AUC was 0.73, sensitivity was 69.2%, and specificity was 85.0%; the cutoff value was 8.8%.</p><p>Conclusions: periostin was implicated in the pathophysiology of ECRS. Periostin shown to be a more useful biomarker than eosinophils in ECRS. Periostin was shown to likely be an important biomarker for pathological severity of ECRS and postoperative recurrence of nasal polyps.</p>
収録刊行物
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- Allergology International
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Allergology International 72 (1), 161-168, 2023
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390295027674957440
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- ISSN
- 14401592
- 13238930
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可