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- Kim Ju Hee
- Department of Pediatrics, Kangdong Sacred Heart Hospital, Hallym University College of Medicine
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- Yi Yoon Young
- Department of Pediatrics, Kangdong Sacred Heart Hospital, Hallym University College of Medicine
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- Ha Eun Kyo
- Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital
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- Cha Hey Ryung
- Department of Data Science, Sejong University College of Software Convergence
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- Han Man Yong
- Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine
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- Baek Hey-Sung
- Department of Pediatrics, Kangdong Sacred Heart Hospital, Hallym University College of Medicine
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<p>Background: Few studies have reported an association between atopic dermatitis and cognitive impairment in children. Therefore, we evaluated the association between atopic dermatitis (AD) and neurodevelopmental dysfunction in children.</p><p>Methods: We analyzed 2,395,966 children born between 2008 and 2012 in Korea. All data were acquired from the databases of the Korean National Health Insurance System. AD was defined as five or more diagnoses before age 24 months. The outcome was suspected neurodevelopmental dysfunction in the gross motor skill, fine motor skill, cognition, language, sociality, and self-care domains of the Korean Developmental Screening Test for Infants and Children at age 6 years. The positive control outcome was defined as attention deficit hyperactive disorder (ADHD). The associations were assessed using ordinal logistic regression, adjusting for asthma and allergic rhinitis.</p><p>Results: Among the eligible children, 89,452 and 30,557 were allocated to the control and AD groups, respectively. In the weighted data, the AD group showed a higher risk of suspected neurodevelopmental dysfunction in the total score (weighted adjusted odds ratio [95% CI] 1.10 [1.05-1.16]), gross motor skills (1.14 [1.04-1.25]), and fine motor skills (1.15 [1.06-1.25]) than the control group. The AD with steroids or hospitalization groups showed an increased risk of suspected neurodevelopmental dysfunction. In addition, the AD group showed a significant association with mental retardation, psychological development disorder, and behavioral and emotional disorders as well as ADHD.</p><p>Conclusions: AD before age 2 years may be associated with an increased risk of neurodevelopmental dysfunction including gross and fine motor skills in the young childhood period.</p>
収録刊行物
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- Allergology International
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Allergology International 72 (1), 116-127, 2023
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390295027675133952
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- ISSN
- 14401592
- 13238930
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可