Recent Advances on Transdermal Vaccine as an Alternative to Injection–Boundary Regional Approach in Membrane Science and Technology–

DOI Web Site
  • Goto Masahiro
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University Advanced Transdermal Drug Delivery System Center, Kyushu University

Bibliographic Information

Other Title
  • 注射に代わる次世代経皮ワクチン研究の最前線 – 膜学における境界領域研究として–

Description

Transdermal drug delivery is receiving a growing concern to alternate conventional drug administration techniques such as oral administration or needle–stick based administration methods. In this review article, we proposed a patch system based on a solid–in–oil nanodispersion technique as a simple and efficient delivery method of drugs, especially protein and peptide vaccines, through the skin. The skin is an attractive route for vaccination because there are many immune cells. We have developed the solid–in–oil nanodisperison technique to deliver pharmaceutical bioactives efficiently through the skin. Solid–in–oil nanodispersions are nanosized drug carriers designed to overcome the skin barrier. Drug administration using a patch is user–friendly and can improve patient compliance. Protein and peptide antigen drugs were efficiently delivered across the intact skin using the solid–in–oil nanodispersions. The technique is potent transcutaneous immunization method without needles.

Journal

  • MEMBRANE

    MEMBRANE 48 (1), 25-30, 2023

    THE MEMBRANE SOCIETY OF JAPAN

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