Viral vector vaccines: efforts to develop vaccines against emerging infectious diseases

DOI Web Site 17 References
  • Watanabe Tokiko
    Department of MolecularVirology, Research Institute for Microbial Diseases, Osaka University

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Other Title
  • 組換えウイルスベクターワクチン：新興感染症に対するワクチン開発の取り組み

Abstract

Vaccines are one of the most effective means of preventing viral infections. Since Edward Jenner invented the world’s first vaccine in 1796, against smallpox, various types of vaccine have been developed, including inactivated vaccines, attenuated live vaccines, recombinant protein vaccines, viral vector vaccines and nucleic acid vaccines. Viral vector vaccines and nucleic acid vaccines （mRNA vaccines and DNA vaccines） have been developed most recently. In these vaccines, genes encoding viral proteins that serve as antigens are introduced into the body. The viral vector is an excellent vaccine delivery system that efficiently delivers antigen genes to target cells, and has been utilized for vaccine development against a variety of emerging infectious diseases, including AIDS, malaria, Ebola hemorrhagic fever, dengue fever, and most recently COVID-19. Here, we provide an overview of viral vector vaccines and discuss recent efforts to develop vaccines against emerging infectious diseases.

Journal

  • Drug Delivery System

    Drug Delivery System 37 (5), 429-436, 2022-11-25

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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