Intercellular interactions in three-dimensional pancreatic tissue during organogenesis and regeneration

DOI Web Site 16 References
  • FURUYAMA Kenichiro
    Dept of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University
  • KAWAGUCHI Yoshiya
    Dept of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University

Bibliographic Information

Other Title
  • 膵発生/再生における細胞系譜と細胞間相互作用の解明

Abstract

<p>The pancreas is a solid organs with a three-dimensional (3D) cellular structure, where cell-to-cell interactions could play key roles in organ development, homeostasis and regeneration as well as diseases including tumorigenesis. To understand the mechanisms underlying those processes, it is important to investigate signaling pathways not only within cells but also between cells.</p><p>Recent advances in experimental techniques including a 3D culture system, Cre/loxP-based genetic lineage tracing and cell ablation models, have allowed us to explore cell-to-cell communications, leading to an improved understanding of tissue behaviors as a cell population. We present recent reeslts to provide a brief overview of intercellular crosstalk in the pancreas.</p>

Journal

  • Suizo

    Suizo 38 (1), 2-9, 2023-02-28

    Japan Pancreas Society

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