Interaction between Enterohemorrhagic Escherichia coli O157:H7 EspFu and IRSp53 induces dynamic membrane remodeling in epithelial cells
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- Morita-Ishihara Tomoko
- Department of Bacteriology I, National Institute of Infectious Diseases, Japan
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- Terajima Jun
- Department of Bacteriology I, National Institute of Infectious Diseases, Japan
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- Watanabe Haruo
- Department of Bacteriology I, National Institute of Infectious Diseases, Japan
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- Izumiya Hidemasa
- Department of Bacteriology I, National Institute of Infectious Diseases, Japan
書誌事項
- タイトル別名
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- Interaction between Enterohemorrhagic <i>Escherichia coli</i> O157:H7 EspFu and IRSp53 Induces Dynamic Membrane Remodeling in Epithelial Cells
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<p>Enterohemorrhagic Escherichia coli (EHEC) O157:H7 induces the formation of filamentous, actin-rich, pedestal-shaped structures beneath bacterial cells that have attached to intestinal epithelial cells. Pedestal formation requires the translocation of EHEC O157:H7 type III effectors. One of these type III effectors, EspFu, consists of an N-terminal signal sequence, which is necessary for the translocation of EspFu into the host cell through a type III secretion system, and almost identical proline-rich repeats (PRRs), which control actin rearrangement and increase the efficiency of actin assembly in the host cell. In this study, we report that insulin receptor tyrosine kinase substrate p53 (IRSp53) in the host cell acts as a binding partner for EspFu. Co-immunoprecipitation and fluorescence microscopy showed specific interactions between EspFu and IRSp53 as well as their co-localization in epithelial cells. Additionally, we demonstrated that the association between EspFu and IRSp53 induces dynamic membrane remodeling in epithelial cells.<tt> </tt></p>
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 62 (5), 351-355, 2009-09-30
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詳細情報 詳細情報について
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- CRID
- 1390295259245256704
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- NII論文ID
- 40016750204
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL書誌ID
- 10368452
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可