The mechanisms of glucose transporter type 4 translocation regulated by insulin receptor signaling

DOI Web Site 18 References

Bibliographic Information

Other Title
  • インスリン受容体シグナルによる糖輸送体GLUT4小胞の膜発現機構

Abstract

<p>Insulin-regulated glucose transport is dependent on glucose transporter GLUT4 translocation to the plasma membrane, which incorporates glucose into the cells, mainly in adipose tissue and skeletal muscle. Insulin receptor signaling can stimulate GLUT4 vesicle transport from perinuclear pool to the plasma membrane via the vesicle transport machinery. At first, insulin signaling is divided to the multiple pathways, such as Akt/PKB and PKC-zeta/lambda. Subsequently, PKC-zeta/lambda activates KIF3, motor protein based on microtubules, and sequentially Akt/PKB activates Myosin-Va, motor protein based on actin filaments. KIF3 motor moves GLUT4 vesicles from perinuclear pool to the end of microtubules, and Myosin-Va transports GLUT4 vesicles from the end of microtubules to the plasma membrane. Here we indicate the machinery of insulin-regulated GLUT4 vesicle translocation, showing that these motor proteins are the destinations of insulin receptor signaling to regulate glucose transport into the cells.</p>

Journal

References(18)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top