Recognition of odor mixtures by odorant receptors

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  • IMAI Takeshi
    Department of Developmental Neurophysiology, Graduate School of Medical Sciences, Kyushu University

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  • 嗅覚受容体によるにおいの混合物の識別機構

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<p>In the olfactory system, individual odorants are recognized by a combination of approximately 400 types of odorant receptors. However, it remains poorly understood how mixtures of multiple odorants are recognized. Recent advances in high-throughput imaging techniques have revealed how mixtures of odorants are recognized by olfactory sensory neurons in vivo. In this review, I describe antagonism and synergy, which happens at the level of odorant receptors, and discuss mechanisms of odor mixture discrimination. I also discuss implications from the recently reported structural analysis of an odorant receptor.</p>

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