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Sleep-related factors and circulating levels of sex hormones in premenopausal Japanese women
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- Nagata Chisato
- Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
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- Wada Keiko
- Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
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- Yamakawa Michiyo
- Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
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- Nakashima Yuma
- Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
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- Hayashi Makoto
- Department of Internal Medicine, Matsunami General Hospital, Gifu 501-6062, Japan
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- Takeda Noriyuki
- Department of Endocrinology and Metabolism, Murakami Memorial Hospital, Asahi University, Gifu 500-8523, Japan
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- Yasuda Keigo
- Department of Internal Medicine, Matsunami General Hospital, Gifu 501-6062, Japan
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Description
<p>Sleep disruption and circadian disruption have been proposed to be risk factors of breast cancer. The present study examined the associations of sleep-related factors, referring to night shift work, sleep habits, and sleep disturbances, with the plasma levels of sex hormones in premenopausal Japanese women. Study participants were 432 women who had regular menstrual cycles less than 40 days long. Information on their history of night shift work and sleep disturbances was obtained using a self-administered questionnaire. Information on their sleep habits, such as usual wake-up times, bedtimes, and ambient light level while sleeping, was obtained in an interview. The participants’ height and weight were measured. Plasma concentrations of estradiol, testosterone, dehydroepiandrosterone sulfate, sex hormone-binding globulin (SHBG), FSH, and LH were also measured. After controlling for the phase of the menstrual cycle and other covariates, more years of night shift work ≥ once a week during the past 10 years was significantly associated with a lower SHBG and a higher free estradiol level. Shorter sleep duration was significantly associated with the higher total, bioavailable, and free testosterone levels. Sleep disturbance by awaking after sleep onset was significantly associated with a high free estradiol level. The data suggest that long-term night shift work, short sleep duration, and arousal during sleep are associated with higher estradiol or testosterone levels in premenopausal women.</p>
Journal
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- Endocrine Journal
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Endocrine Journal 70 (3), 267-273, 2023
The Japan Endocrine Society
