Evaluation of carbonate apatite as a bone substitute in rat extraction sockets from the perspective of mesenchymal stem cells

  • TAKAHASHI Ryosuke
    Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University Division of Advanced Dental Devices and Therapeutics, Faculty of Dental Science, Kyushu University
  • ATSUTA Ikiru
    Division of Advanced Dental Devices and Therapeutics, Faculty of Dental Science, Kyushu University
  • NARIMATSU Ikue
    Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University
  • YAMAZA Takayoshi
    Department of Molecular Cell Biology and Oral Anatomy, Faculty of Dental Science, Kyushu University
  • ZHANG Xiaoxu
    Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University Division of Advanced Dental Devices and Therapeutics, Faculty of Dental Science, Kyushu University
  • EGASHIRA Yuki
    Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University Division of Advanced Dental Devices and Therapeutics, Faculty of Dental Science, Kyushu University
  • KOYANO Kiyoshi
    Division of Advanced Dental Devices and Therapeutics, Faculty of Dental Science, Kyushu University
  • AYUKAWA Yasunori
    Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University

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説明

<p>Carbonate apatite (CO3Ap) is a major inorganic bone component and an effective bone substitute. To clarify the function of CO3Ap, we compared differences among CO3Ap, hydroxyapatite (HAp), and β-tricalcium phosphate (β-TCP) by focusing on mesenchymal stem cells (MSCs) that have a role in wound healing. For in vivo experiments, maxillary molars were removed and the bone substitute was inserted. MSC accumulation around extraction sockets was significantly promoted in CO3Ap and β-TCP groups. For in vitro experiments, MSCs were cultured with bone substitutes. The differentiation potential and amount of calcium deposition were significantly lower in CO3Ap and HAp groups than in the β-TCP group. Increases in insulin-like growth factor-I and vascular endothelial growth factor were found only in the CO3Ap group. CO3Ap-filled extraction sockets accumulated MSCs, and MSCs cultured in the presence of CO3Ap produced large amounts of growth factors. These results suggest that CO3Ap promotes healing of tooth extraction sockets.</p>

収録刊行物

  • Dental Materials Journal

    Dental Materials Journal 42 (2), 282-290, 2023-03-25

    一般社団法人 日本歯科理工学会

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