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Structural insight of peptide-ligand recognition by plant membrane receptors
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- Okuda Satohiro
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo
Bibliographic Information
- Other Title
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- X 線結晶構造解析から捉えた受容体のペプチドリガンド認識機構
- Xセン ケッショウ コウゾウ カイセキ カラ トラエタ ジュヨウタイ ノ ペプチドリガンド ニンシキ キコウ
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Description
<p>Plants have generated divergent peptide ligands and corresponding membrane receptors to control their growth and development, as well as various aspects of physiology. Secreted-peptide ligands are mainly recognized by membrane receptor kinases that mediate cell-cell communication. In Arabidopsis, more than 1,000 genes are putative secreted peptides and ~600 genes are annotated as receptor-like kinases. However, several pairs of the peptide ligands and the cognate receptors are identified and mechanistically characterized, many of them remain orphan ligands and receptors. In the past 5 years, structural and biochemical studies have revealed how the short liner peptides with post-translational modification are perceived by the corresponding receptors with leucine-rich repeats (LRR) ectodomain at a molecular level. The short linear peptides are recognized by the LRR-type receptors and co-receptors in a conserved manner. Moreover, the recent structural study has implied a new mode of peptide recognition by LRR receptors. This short review summarizes recognition mode of the secreted peptides by the LRR-type receptors and receptor-activation mechanisms that have been structurally characterized in recent studies.</p>
Journal
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- PLANT MORPHOLOGY
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PLANT MORPHOLOGY 34 (1), 29-36, 2022
The Japanese Society of Plant Morphology