Exercise Combined with Amino Acids Intake Induces Brown-like AdipocyteFormation and Obtains More Benefits Than Just Prevention of Obesity

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  • Tsuda Takanori
    College of Bioscience and Biotechnology and Graduate School of Bioscience and Biotechnology, Chubu University

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  • 運動とアミノ酸の併用によるマイオカインを介した褐色脂肪細胞化誘導と肥満予防を超える恩恵への発展
  • ウンドウ ト アミノサン ノ ヘイヨウ ニ ヨル マイオカイン オ カイシタ カッショク シボウ サイボウカ ユウドウ ト ヒマン ヨボウ オ コエル オンケイ エ ノ ハッテン

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Abstract

<p>Exercise combined with food-derived factors may have significant effects on the suppression of body fat accumulation. Several trials suggested that amino acid mixtures containing alanine, arginine, and phenylalanine （AA-Mix） combined with exercise can significantly reduce abdominal fat in overweight adults and high-fat diet-induced obesity in mice. We therefore hypothesized that combining AA-Mix and exercise would significantly induce brown-like adipocyte formation, whereas either administration of AA-Mix or exercise alone would not. Administration of AA-Mix （1 g/kg） combined with exercise for 4 weeks significantly induced formation of brown-like adipocytes in inguinal white adipose tissue （iWAT） in mice, although AA-Mix or exercise alone did not. To clarify the mechanism that exercise combined with AA-Mix induces brown-like adipocyte formation, mice were loaded a single acute exercise for 1 h after a single administration of AA-Mix, then the expression of fibroblast growth factor 21 （FGF21） and iterleukin-6 （IL-6） were examined. Plasma FGF21 concentration and the mRNA levels in the liver and iWAT did not differ between the groups after 0 and 1 h of exercise. On the contrary, plasma IL-6 concentration was significantly increased in the exercise combined with AA-Mix group compared with the exercise alone group after 1 h of exercise. These results suggest that IL-6 is involved with exercise combined with AA-Mix induced brown-like adipocyte formation. These findings demonstrate the unique effect of exercise combined with AA-Mix for inducing beige adipocyte formation.</p>

Journal

  • DESCENTE SPORTS SCIENCE

    DESCENTE SPORTS SCIENCE 42 (0), 122-129, 2022-06-20

    THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION OF SPORTS SCIENCE

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