A case of early syphilitic hepatitis that was rapidly cured by a single intramuscular injection of a continuous penicillin preparation

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  • Kobayashi Kiyoyuki
    Department of Gastroenterology and Hepatology, HITO Medical Center Division of Innovative Medicine for Hepatobiliary and Pancreatology, Faculty of Medicine, Kagawa University
  • Nomura Takako
    Department of Gastroenterology and Hepatology, HITO Medical Center Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University
  • Akaiwa Yuzuru
    Department of Gastroenterology and Hepatology, HITO Medical Center
  • Ogi Tomohiro
    Department of Gastroenterology and Hepatology, HITO Medical Center
  • Ogi Maki
    Department of Gastroenterology and Hepatology, HITO Medical Center
  • Ishikawa Kayo
    Department of Gastroenterology and Hepatology, HITO Medical Center
  • Ono Masafumi
    Department of Gastroenterology and Hepatology, HITO Medical Center Division of Innovative Medicine for Hepatobiliary and Pancreatology, Faculty of Medicine, Kagawa University
  • Masaki Tsutomu
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University

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Other Title
  • 持続性ペニシリン製剤単回筋注により速やかに治癒が得られた早期梅毒性肝炎の一例
  • ジゾクセイ ペニシリン セイザイタンカイキン チュウ ニ ヨリ スミヤカ ニ チユ ガ エラレタ ソウキ バイドクセイ カンエン ノ イチレイ

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Abstract

<p>A male patient in his 50s who complained of general malaise, itchy skin, and brown urine was admitted to our hospital. Both hepatitis virus markers and autoantibodies were negative. He developed a rash that appeared on his limbs and trunk, a thorough history revealed two months of contact with the sex business, raising the possibility of syphilis infection. Early-stage syphilis (stage 2) and early-stage syphilitic hepatitis were determined to exist. A single-dose benzylpenicillin benzathine hydrate (BPB) intramuscular injection, newly available in Japan since January 2022, and suitable for early treatment of syphilis, was administered. The rash and liver failure and syphilis were all quickly resolved. Although uncommon, early-stage syphilitic hepatitis should be taken into account as a possible cause of liver damage. No earlier publications have used intramuscular BPB injection as a treatment for early-stage syphilitic hepatitis in Japan, hence we present this case together with a literature review.</p>

Journal

  • Kanzo

    Kanzo 64 (4), 194-200, 2023-04-01

    The Japan Society of Hepatology

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