A CASE OF RECTAL INVASION BY NEUROENDOCRINE DIFFERENTIATED PROSTATE CANCER FORMING A LARGE SUBMUCOSAL TUMOR IN THE RECTUM

  • MIZUE Ryutaro
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University.
  • IHARA Yutaro
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University.
  • TORISU Takehiro
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University.
  • KAWATOKO Shinichiro
    Department of Anatomic Pathology, Pathological sciences, Graduate School of Medical Sciences, Kyushu University.
  • FUJIWARA Minako
    Department of Pathology, National Hospital Organization Kyushu Medical Center.

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Other Title
  • 神経内分泌分化した前立腺癌による直腸転移の1例

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<p>A 72-year-old man was diagnosed with prostate cancer 4 years ago and underwent heavy particle and hormone therapies at another hospital. A contrast-enhanced computed tomography (CT) scan, performed because of elevated hepatobiliary enzymes, did not show any abnormalities in the prostate. It did, however, show multiple hepatic masses, a mass shadow in the rectum, and enlarged surrounding lymph nodes. CS revealed a 40 mm submucosal tumor in the rectum with a depression in the apex. The tumor was biopsied and diagnosed as endocrine cell carcinoma. Chemotherapy initiation reduced the tumor size; however, a genomic analysis using a gene panel revealed the presence of prostate cancer-specific fusion gene TMPRSS2-ERG. This report describes a rare case in which neuroendocrine differentiation of prostate cancer was seen after hormone therapy, and the metastatic lesion grew rapidly and invaded the rectum.</p>

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