Mediation Analysis of The Relationship between Pruritus and Signs of Eczema Improvements in Patients with Atopic Dermatitis Undergoing Nemolizumab Intervention

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  • ネモリズマブのアトピー性皮膚炎の皮疹改善効果に対するそう痒改善の寄与：Mediation analysis法による検討
  • ネモリズマブ ノ アトピーセイ ヒフエン ノ ヒシンカイゼン コウカ ニ タイスル ソウ ヨウカイゼン ノ キヨ:Mediation analysisホウ ニ ヨル ケントウ

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Abstract

<p>Nemolizumab is a humanized monoclonal antibody against Interleukin (IL) -31 receptor A. We implemented a mediation analysis to evaluate the interaction between pruritus and signs of eczema improvements using data from a Phase 3 clinical study of nemolizumab in patients with atopic dermatitis. The results of this analysis indicated that a large part of the improvement in signs of eczema during the early period (by week 4) was attributable to the direct effect of nemolizumab treatment. The indirect effect of nemolizumab treatment on signs of eczema through pruritus improvement increased during the later period (after 8 weeks). We report that the efficacy of nemolizumab on pruritus contributes to inhibiting the itch-scratch cycle and results in further improvement of the signs of eczema.</p>

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