Correlation between the Timing or Dose of Preoperative Radiation Therapy and Surgical Site Infection in Spinal Metastasis Patients

DOI
  • Sugita Shurei
    Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
  • Fujiwara Masanori
    Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
  • Morita Euan
    Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
  • Ogiso Sawako
    Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
  • Koyama Takuma
    Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
  • Hozumi Takahiro
    Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital

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Other Title
  • 脊椎転移術前の放射線治療のタイミング・線量と術後感染の関連

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Abstract

<p>Introduction: Previous report showed that history of preoperative radiotherapy was a risk factor for surgical site infection (SSI) in patients with spinal metastases, who underwent surgery of affected spine. This study aimed to clarify the correlation between the timing or dose of radiation and SSI.</p><p>Methods: Participants comprised 113 patients who underwent surgery for treating spinal metastases between January 2004 and December 2014. All patients had a history of preoperative radiotherapy for the affected spine. Patients who suffered SSI within 1 month after surgery were categorized as infected, and all others were categorized as noninfected. We evaluated and compared the two groups based on the period between preoperative radiotherapy and surgery (days), and total dose of radiation. We evaluated and compared the SSI rate among four groups, classified by the period, super-early (within 1 week), early (within 1 month), late (1 month-1 year), and super-late (>1 year). </p><p>Results: The median period did not differ between infected and noninfected groups (278 and 360 days). Total dose of radiation also did not differ. The rate of SSI did not differ in the super-early (7.7%), early (7.7%), late (8.6%), and super-late groups (9.6%). </p><p>Conclusions: The timing or dose of preoperative radiation therapy did not correlate with the risk of SSI in spinal metastasis patients.</p>

Journal

  • Journal of Spine Research

    Journal of Spine Research 14 (5), 799-802, 2023-05-20

    The Japanese Society for Spine Surgery and Related Research

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