A Clinical Study of 31 Cases with Submandibular Gland Carcinoma: A 22-year Review

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  • Sasaki Akinori
    Department of Otolaryngology & Head and Neck Surgery, Osaka Medical and Pharmaceutical University
  • Jinnin Tsuyoshi
    Department of Otolaryngology & Head and Neck Surgery, Osaka Medical and Pharmaceutical University
  • Higashino Masaaki
    Department of Otolaryngology & Head and Neck Surgery, Osaka Medical and Pharmaceutical University
  • Terada Tetsuya
    Department of Otolaryngology & Head and Neck Surgery, Osaka Medical and Pharmaceutical University
  • Kawata Ryo
    Department of Otolaryngology & Head and Neck Surgery, Osaka Medical and Pharmaceutical University

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Other Title
  • 顎下腺癌31例の臨床的検討：当科における22年間の経験
  • ガクカセンガン 31レイ ノ リンショウテキ ケントウ : トウ カ ニ オケル 22ネンカン ノ ケイケン

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Abstract

<p>　Submandibular gland cancer are rare, accounting for 25% of major salivary gland cancer. We evaluated the management and outcomes of submandibular gland cancer treated at Osaka Medical and Pharmaceutical University Hospital from 1999 to 2021. Our study population of 31 patients included 23 men and 8 women with a median age of 65 years. The most common histological type was adenoid cystic carcinoma and salivary duct carcinoma, followed by mucoepidermoid carcinoma and carcinoma ex pleomorphic adenoma. High-grade tumors were observed in 19 (61%) patients. The Kaplan Meier 5-year estimated disease-specific survival was 59.2% in all cases, and 100%, 71.1%, 100%, and 25.0% for stage I to IV, respectively. The cases with high stage, node positive, advanced T, and high-grade were poor prognosis. Advanced stage, node positive, and advanced age were proved to be significant predictors of recurrent cases. The survival rate of the submandibular gland cancer was poor compared with the parotid gland cancer because there were the cases with the submandibular gland cancer have no low/intermediate-grade types in such as basal cell carcinoma, secretory carcinoma, and epithelial-myoepithelial carcinoma, which are major type in the parotid gland cancer.</p>

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