Glymphatic System Activity May Be Disrupted in Moyamoya Disease : The Diffusion Tensor Image Analysis Along the Perivascular Space (DTI-ALPS) Study [Presidential Award Proceedings]

DOI Web Site 1 Citations 8 References
  • HARA Shoko
    Department of Neurosurgery, Tokyo Medical and Dental University Department of Radiology, Juntendo University Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology
  • KIKUTA Junko
    Department of Radiology, Juntendo University
  • TAKABAYASHI Kaito
    Department of Radiology, Juntendo University
  • KAMAGATA Koji
    Department of Radiology, Juntendo University
  • HAYASHI Shihori
    Department of Neurosurgery, Tokyo Medical and Dental University Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology
  • INAJI Motoki
    Department of Neurosurgery, Tokyo Medical and Dental University Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology
  • TANAKA Yoji
    Department of Neurosurgery, Tokyo Medical and Dental University
  • HORI Masaaki
    Department of Radiology, Juntendo University Department of Radiology, Toho University Omori Medical Center
  • ISHII Kenji
    Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology
  • NARIAI Tadashi
    Department of Neurosurgery, Tokyo Medical and Dental University Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology
  • TAOKA Toshiaki
    Department of Innovative Biomedical Visualization, Nagoya University
  • NAGANAWA Shinji
    Department of Radiology, Nagoya University
  • AOKI Shigeki
    Department of Radiology, Juntendo University
  • MAEHARA Taketoshi
    Department of Neurosurgery, Tokyo Medical and Dental University

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Other Title
  • もやもや病にGlymphatic system機能不全は存在するか？—DTI-ALPS indexによる評価—［大会長賞記録］

Abstract

<p>　This study aimed to investigate diffusion along the perivascular space (DTI-ALPS index), which may reflect glymphatic system function in adult patients with moyamoya disease. We evaluated 46 patients with moyamoya disease using multishell diffusion magnetic resonance imaging, perfusion parameters of 15O-gas positron emission tomography, and cognitive tests. Diffusion data were analyzed to evaluate the DTI-ALPS index and free water parameters of each hemisphere and compared with the DTI-ALPS index of 34 age-sex-matched normal controls. Compared to normal controls, patients with moyamoya disease showed a significantly lower DTI-ALPS index (mean (standard deviation)=1.93 (0.25) vs. 1.64 (0.22) ; p<0.001). The DTI-ALPS index of patients with moyamoya disease was significantly correlated with perfusion parameters (vs. mean transit time, r=0.33), free water parameters (vs. free water fraction created from free water eliminated diffusion tensor imaging of the cortex, r=−0.24), and executive function (vs. trail making test part B, r=−0.47). These results indicate that glymphatic system dysfunction may exist, correlate with the degree of hemodynamic disturbance, lead to increased parenchymal free water, and be related to cognitive dysfunction in adult patients with moyamoya disease.</p>

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