A Case of Tracheobronchial Chondritis as an Immune-Related Adverse Event after Administration of Nivolumab in Treatment of Submandibular Carcinoma

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  • 顎下腺癌に対してニボルマブ投与後に発症した気管軟骨炎
  • ガクカセンガン ニ タイシテ ニボルマブ トウヨ ゴ ニ ハッショウ シタ キカン ナンコツエン

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Abstract

<p>Tracheobronchial chondritis is a rare immune-related adverse event (irAE) relevant to nivolumab. The patient was a 54-year-old man diagnosed with submandibular carcinoma (cT4aN3M0). He was judged to have a partial response (PR) during nivolumab treatment. During the administration of nivolumab, coughing and discomfort in the precordial chest appeared for 2 weeks. Chest CT showed tracheal wall thickening, and chest X-ray showed tracheal narrowing. His symptoms and imaging findings improved with oral steroid administration. Since recurrence was observed with reduction of the steroid dose, oral administration is being continued, and the patient is under observation. Tracheobronchial chondritis has characteristic findings on chest CT and X-ray examinations. It is rare but sometimes fatal and may occur after relatively long-term administration of nivolumab. Since the symptoms are similar to pneumonia, it is important to differentiate this disease from pneumonia if respiratory symptoms occur during administration of nivolumab.</p>

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