Blood Dioxin Concentrations and their Tendencies Examined in Family Members Living with Certificated Yusho Patients and Considered as Yusho Patients

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  • 同居家族条件によって認定された油症患者の血液中ダイオキシン類濃度と傾向
  • ドウキョ カゾク ジョウケン ニ ヨッテ ニンテイ サレタ ユショウ カンジャ ノ ケツエキ チュウ ダイオキシンルイ ノウド ト ケイコウ

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Abstract

We performed congener specific analysis of dioxins using HRGC/HRMS and determined their lipid based concentrations in blood samples collected from 175 family members living with certificated Yusho patients and considered as Yusho patients (Family members living with Yusho patients) during annual Yusho examinations between 2013 and 2021. When concentration of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) was compared in eleven Family members living with Yusho patients, undergoing examinations among the nine years, the longitudinal concentrations in the respective individuals hardly changed over these years. Mean concentration of 2,3,4,7,8-PeCDF in blood from 175 Family members living with Yusho patients was calculated as 25 pg/g-fat, which was higher than the mean value of 12 pg/g-fat in blood from 409 Yusho-suspected (non-registered) persons. The rates of persons with blood 2,3,4,7,8-PeCDF concentrations below 50 pg/g-fat in the entire Family members livingwith Yusho patients occupied approx. 90 %, on the other hand, concentrations above 50 pg/g-fat, defined as high concentration in Yusho criteria, were also found in fourteen Family members living with Yusho patients.

Journal

  • 福岡醫學雜誌

    福岡醫學雜誌 114 (1), 10-16, 2023-03-25

    Fukuoka Medical Association

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