書誌事項
- タイトル別名
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- Developing Evaluation Method for Peripheral Sensitization in Cultured Sensory Neurons
抄録
<p>Peripheral sensitization, decrease in pain threshold in sensory neurons, can cause chronic pain. Little is known about how peripheral sensitization led to chronic pain. Here, we aimed to develop a method for evaluating peripheral sensitization in cultured sensory neurons with electrical recording. Sensory neurons from rat dorsal root ganglion were cultured on high-density microelectrode arrays, and their activity was evoked by capsaicin stimulation with or without substance P. Fluorescent imaging-based electrode selection effectively selected five times as many capsaicin-sensitive sensory neurons as the existing method. Peripheral sensitization by substance P was detected from 31.9% of selected sensory neurons, and majority of these neurons co-expressed capsaicin and substance P receptors. These results indicate that our method is suitable for evaluating peripheral sensitization by substance P in cultured sensory neurons.</p>
収録刊行物
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- 電気学会論文誌Ｃ（電子・情報・システム部門誌）
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電気学会論文誌Ｃ（電子・情報・システム部門誌） 143 (7), 641-648, 2023-07-01
一般社団法人 電気学会
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詳細情報 詳細情報について
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- CRID
- 1390296666497079552
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- ISSN
- 13488155
- 03854221
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可