Clinical Outcomes in Sinonasal Mucosal Malignant Melanoma Patients who Receive Multidisciplinary Treatment

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  • Tsukamoto Koji
    Department of Otorhinolaryngology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital
  • Kawakita Daisuke
    Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduated School of Medical Sciences
  • Matoba Takuma
    Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduated School of Medical Sciences
  • Takano Gaku
    Department of Otorhinolaryngology, Nagoya City University West Medical Center
  • Oguri Keisuke
    Department of Otorhinolaryngology, Konan Kosei Hospital
  • Murashima Akihiro
    Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduated School of Medical Sciences
  • Minohara Kiyoshi
    Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduated School of Medical Sciences
  • Sumiya Shogo
    Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduated School of Medical Sciences
  • Nakai Kazuyuki
    Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduated School of Medical Sciences
  • Iwaki Sho
    Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduated School of Medical Sciences
  • Tsuge Hiroshi
    Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduated School of Medical Sciences
  • Tanaka Nobukazu
    Department of Head and Neck Medical Oncology, National Cancer Center Hospital East
  • Imaizumi Sae
    Department of Head and Neck Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research
  • Kondo Ayano
    Department of Otorhinolaryngology, Kainan Hospital
  • Hojo Wataru
    Department of Otorhinolaryngology, Anjo Kosei Hospital
  • Iwata Hiromitsu
    Department of Radiation Oncology, Nagoya Proton Therapy Center, Nagoya City University West Medical Center
  • Sanuki Tetsuji
    Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduated School of Medical Sciences
  • Iwasaki Shinichi
    Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduated School of Medical Sciences

Bibliographic Information

Other Title
  • 集学的治療を行った鼻腔粘膜悪性黒色腫の臨床的検討
  • シュウガクテキ チリョウ オ オコナッタ ビコウ ネンマク アクセイ コクショク シュ ノ リンショウテキ ケントウ

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Abstract

<p>　　Mucosal malignant melanoma accounts for about 10% of all cases of malignant melanoma, and in the head and neck region, these tumors most frequently arise in the sinonasal cavities. Radical resection + postoperative radiotherapy is considered as the standard treatment, but distant metastases are common and the prognosis is poor. In recent years, the efficacy of proton beam therapy and immune checkpoint inhibitor (ICI) therapy, as novel treatment options, has been reported. We reviewed the data of 14 cases of sinonasal mucosal malignant melanoma who received multidisciplinary treatment at Nagoya City University Hospital between January 2014 and April 2021. The median age of the patients, consisting of 6 men and 8 women, was 76 years. As the initial treatment, surgery was performed in 3 cases, proton beam therapy in 9 cases, and ICI therapy in 2 cases (distant metastases). The response rate to proton beam therapy was 55.6%. Including cases that developed recurrence, 12 cases received anti-PD-1 therapy, 1 received anti-CTLA4 therapy, and 3 received anti-PD-1 + anti-CTLA4 therapy. The median survival duration after ICI treatment was 17 months (range: 3-58 months). Although patients with recurrence in poor general condition did not show good responses to ICI therapy, even patients who were 80 years old or older who were in good general condition could receive ICI therapy for a long period. In the future, it is necessary to develop individualized treatment strategies that would take into account the timing of ICI therapy.</p>

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